01 - Preheat oven to 350°F. Line a 12-cup muffin tin with paper liners and set aside.
02 - In a large mixing bowl, whisk together the all-purpose flour, cocoa powder, granulated sugar, baking soda, baking powder, and salt until evenly distributed.
03 - Add the room-temperature buttermilk, vegetable oil, eggs, and vanilla extract to the dry mixture. Beat until just combined, then pour in the hot water and stir until the batter is smooth. The batter will be thin — this is normal.
04 - Divide the batter evenly among the prepared liners, filling each cavity about two-thirds full.
05 - Bake for 18 to 20 minutes, or until a toothpick inserted into the center of a cupcake comes out clean. Transfer to a wire rack and let cool completely before filling or glazing.
06 - Using an electric mixer, beat the softened unsalted butter on medium speed until light and creamy. Add the powdered sugar and beat for 1 minute. Blend in the marshmallow creme and vanilla extract, beating until the filling is fluffy and smooth. If the consistency is too stiff, add milk one teaspoon at a time until spreadable.
07 - Once the cupcakes are completely cool, use a small knife or cupcake corer to remove a small portion from the center of each cupcake. Reserve the removed tops if desired. Fill each cavity with the cream filling using a piping bag, then replace the reserved tops.
08 - Heat the heavy cream in a small saucepan until steaming — do not let it boil. Pour the hot cream over the semi-sweet chocolate chips and let stand for 2 minutes. Stir until the ganache is smooth and glossy.
09 - Spoon the ganache over the tops of the cooled cupcakes, or dip each cupcake top directly into the ganache. Allow the glaze to set at room temperature.
10 - Stir together the powdered sugar and milk until a smooth, pipeable icing forms — adjust with additional milk as needed. Transfer to a piping bag fitted with a fine round tip (or a zip-top bag with a tiny corner snipped). Pipe the classic curly swirl across the top of each glazed cupcake.
11 - Let the ganache and icing set fully before serving. Store leftovers in the refrigerator for up to 3 days; allow to come to room temperature before enjoying for the best texture.