01 - Heat a large skillet over medium-high heat. Add the ground beef, salt, pepper, smoked paprika, and garlic powder. Break up the meat with a spatula and stir occasionally until browned and cooked through, approximately 7–8 minutes. Drain excess fat if necessary.
02 - In a small bowl, whisk together the mayonnaise, ketchup, mustard, pickle relish, apple cider vinegar, smoked paprika, salt, and pepper until smooth and well combined. Set aside until ready to serve.
03 - Divide the chopped romaine lettuce evenly among four large serving bowls, creating a bed of greens for each portion.
04 - Top each lettuce bed with equal portions of the cooked ground beef. Arrange cherry tomatoes, shredded cheddar cheese, red onion slices, pickle slices, and diced avocado over the beef in each bowl.
05 - Drizzle the prepared burger sauce generously over each bowl. Serve immediately while the beef is still warm.